enoxaparin

Contraindication/Precautions

Contraindicated in:

• Hypersensitivity ;

• Hypersensitivity to benzyl alcohol (multidose vial);

• Positive in vitro test for antiplatelet antibody in the presence of enoxaparin;

• Active, major bleeding.

• Severe hepatic or renal disease (adjust dose if CCr <30 mL/min);

• Retinopathy (hypertensive or diabetic);

• Uncontrolled hypertension;

• Recent history of ulcer disease;

• History of congenital or acquired bleeding disorder;

• Women <45 kg and men <57 kg (↑ exposure to enoxaparin with ↑ risk of bleeding; weight-adjusted dosing recommended);

• Malignancy;

• Geri: May have ↑ risk of bleeding due to age-related ↓ in renal function;

• OB: Lactation: Pedi: Safety not established; should not be used in pregnant patients with prosthetic heart valves without careful monitoring.

• Severe uncontrolled hypertension;

• Bacterial endocarditis;

• Bleeding disorders;

• GI bleeding/ulceration/pathology;

• Hemorrhagic stroke;

• Recent CNS or ophthalmologic surgery;

• History of thrombocytopenia related to heparin;

• Spinal/epidural anesthesia or spinal puncture (↑ risk of spinal/epidural hematoma that may lead to long-term or permanent paralysis).