Pharmacokinetics

Absorption: 80% absorbed following oral administration

Distribution: Enters breast milk

Metabolism and Excretion: Mostly metabolized by the liver (primarily CYP3A4 and CYP2C19 isoenzymes); 7% excreted unchanged by kidneys

Half-life: Increased in geriatric patients and patients with hepatic impairment

TIME/ACTION PROFILE (antidepressant effect)

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