Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Concurrent MAO inhibitors

• Concurrent use of citalopram

• History of mania (may activate mania/hypomania)

• History of seizures

• Patients at risk for suicide

• Hepatic impairment (dose reduction recommended)

• Geri: Hepatic impairment or geriatric patients ( doses recommended)

• Severe renal impairment

• OB: Neonates exposed to SSRI in 3rd trimester may develop drug discontinuation syndrome including respiratory distress, feeding difficulty, and irritability. Weigh risks and benefits

• Lactation: May cause adverse effects in infant; risk/benefit should be considered

• Pedi: May risk of suicide attempt/ideation especially during early treatment or dose adjustment in children/adolescents (unlabeled for pediatric use)

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