Interactions

Drug-Drug

• May alter requirement for warfarin , oral hypoglycemic agents , or insulins

• Barbiturates , carbamazepine , or rifampin may ↓ effectiveness

• Smoking ↑ risk of adverse CV reactions

• Erythromycin , clarithromycin , itraconazole , ketoconazole , and ritonavir may ↑ risk of adverse effects

Drug-Natural Products
Grapefruit juice may ↑ risk of adverse effects

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