Interactions

Drug-Drug

• ↑ activity of warfarin

• Rifampin , rifabutin , and isoniazid ↓ levels

• Fluconazole at doses >200 mg/day may inhibit the CYP3A4 enzyme system and effect the activity of drugs metabolized by this system

• ↑ hypoglycemic effects of tolbutamide , glyburide , or glipizide

• ↑ levels and risk of toxicity from cyclosporine , rifabutin , tacrolimus , theophylline , zidovudine , alfentanil , and phenytoin

• ↑ levels and effects of benzodiazepines , zolpidem , bispirone , nisoldipine , tricyclic antidepressants , and losartan

• May ↑ risk of bleeding with warfarin

• May antagonize effects of amphotericin B

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