Absorption: Minimal absorption (5–10%) after topical application.
Distribution: Widely distributed; concentrates and persists in tumors.
Metabolism and Excretion: Metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.
Half-life: 20 hr.
TIME/ACTION PROFILE (IV = effects on blood counts, Top = dermatologic effects)
|IV||1–9 days||9–21 days (nadir)||30 days|
|Top||2–3 days||2–6 wk||1–2 mo|