Pharmacokinetics
Absorption: Minimal absorption (5–10%) after topical application.
Distribution: Widely distributed; concentrates and persists in tumors.
Metabolism and Excretion: Metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.
Half-life: 20 hr.
TIME/ACTION PROFILE (IV = effects on blood counts, Top = dermatologic effects)
| ROUTE | ONSET | PEAK | DURATION |
| IV | 1–9 days | 9–21 days (nadir) | 30 days |
| Top | 2–3 days | 2–6 wk | 1–2 mo |
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