Absorption: Minimal absorption (510%) after topical application.
Distribution: Widely distributed; concentrates and persists in tumors.
Metabolism and Excretion: Metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.
Half-life: 20 hr.
TIME/ACTION PROFILE (IV = effects on blood counts, Top = dermatologic effects)
|IV||19 days||921 days (nadir)||30 days|
|Top||23 days||26 wk||12 mo|