Pharmacokinetics

Absorption: Well absorbed after oral administration

Distribution: Crosses the blood-brain barrier

Protein Binding: 94.5%

Metabolism and Excretion: Converted by the liver to norfluoxetine (primarily by CYP2D6 isoenzyme), another antidepressant compound; the CYP2D6 enzyme system exhibits genetic polymorphism (~7% of population may be poor metabolizers and may have significantly ↑ fluoxetine concentrations and an ↑ risk of adverse effects). Fluoxetine and norfluoxetine are mostly metabolized by the liver; 12% excreted by kidneys as unchanged fluoxetine, 7% as unchanged norfluoxetine

Half-life: 1–3 days (norfluoxetine 5–7 days)

TIME/ACTION PROFILE (antidepressant effect)

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