Pharmacokinetics

Absorption: Well absorbed after oral administration

Distribution: Widely distributed; crosses blood-brain barrier. Probably crosses the placenta and enters breast milk. Accumulation of drug occurs with chronic dosing

Protein Binding: 97% (one of the active metabolites)

Metabolism and Excretion: Metabolized by the liver; some metabolites have hypnotic activity

Half-life: 2.3 hr (half-life of active metabolite may be 30–200 hr).

TIME/ACTION PROFILE (hypnotic activity)

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