Interactions

Drug-Drug

• Concurrent use with alcohol, antidepressants, antihistamines, and opioids may result in additive CNS depression

• Cimetidine, hormonal contraceptives, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propoxyphene, propranolol, or valproic acid may metabolism of flurazepam, enhancing its actions

• May efficacy of levodopa

• Rifampin or barbiturates may metabolism and decrease effectiveness of flurazepam

• Sedative effects may be by theophylline

Drug-Natural Products
Concomitant use of kava, valerian, chamomile, or hops can CNS depression

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