Implementation

Adequately hydrate patient with 750–1000 mL of 0.9% NaCl or D5W before first infusion to establish diuresis, then administer 750–1000 mL with 120 mg/kg of foscarnet or 500 mL with 40–60 mg/kg of foscarnet with each dose to prevent renal toxicity

IV Adminstration:

• Intermittent Infusion:

Diluent: May be administered via central line undiluted. If administered via peripheral line, must be diluted with D5W or 0.9% NaCl to prevent vein irritation. Do not administer solution that is discolored or contains particulate matter. Use diluted solution within 24 hr
Concentration: Undiluted: 24 mg/mL; Diluted: 12 mg/mL
Dose is based on patient weight; excess solution may be discarded from bottle before administration to prevent overdosage
Patients who experience progression of CMV retinitis during maintenance therapy may be re-treated with induction therapy followed by maintenance therapy

• Rate:
Administer at a rate not to exceed 1 mg/kg/min
Infuse solution via infusion pump to ensure accurate infusion rate

• Y-Site Compatibility:

» aldesleukin

» amikacin

» aminophylline

» ampicillin

» aztreonam

» bivalirudin

» carboplatin

» cefazolin

» cefoperazone

» cefoxitin

» ceftazidime

» ceftizoxime

» ceftriaxone

» cefuroxime

» chloramphenicol

» cimetidine

» cisplatin

» clindamycin

» cyclophosphamide

» cytarabine

» dactinomycin

» daptomycin

» dexamethasone sodium phosphate

» dexmedetomidine

» diltiazem

» docetaxel

» dopamine

» doripenem

» ertapenem

» erythromycin lactobionate

» etoposide

» etoposide phosphate

» fenoldopam

» fluconazole

» flucytosine

» fludarabine

» fluorouracil

» furosemide

» gemcitabine

» gentamicin

» granisetron

» heparin

» hydrocortisone

» hydromorphone

» ifosfamide

» imipenen-cilastatin

» linezolid

» mechlorethamine

» methotrexate

» metoclopramide

» metronidazole

» morphine

» nafcillin

» nesiritide

» octreotide

» oxacillin

» oxaliplatin

» oxytocin

» paclitaxel

» palonosetron

» pantoprazole

» pemetrexed

» penicillin G potassium

» phenytoin

» piperacillin/tazobactam

» ranitidine

» tacrolimus

» teniposide

» thiotepa

» ticarcillin/clavulanate

» tigecycline

» tirofiban

» tobramycin

» vincristine

» voriconazole

• Y-Site Incompatibility: Manufacturer recommends that foscarnet not be administered concurrently with other drugs or solutions in the same IV catheter except D5W or 0.9% NaCl

» acyclovir

» amphotericin B colloidal

» caspofungin

» diazepam

» digoxin

» diphenhydramine

» dobutamine

» doxorubicin

» droperidol

» epirubicin

» ganciclovir

» haloperidol

» leucovorin

» midazolam

» mitoxantrone

» pentamidine

» prochlorperazine

» promethazine

» trimetrexate

» vinorelbine

foscarnet is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.