Pharmacokinetics

Absorption: Well absorbed after oral administration by active transport. At larger doses, transport becomes saturated and absorption decreases (bioavailability ranges from 60% for a 300-mg dose to 35% for a 1600-mg dose)

Distribution: Crosses blood-brain barrier; enters breast milk

Metabolism and Excretion: Eliminated mostly by renal excretion of unchanged drug

Half-life: 5–7 hr (normal renal function); up to 132 hr in anuria

TIME/ACTION PROFILE (blood levels)

gabapentin is a sample topic found in Davis's Drug Guide. All other sections of this record are viewable by clicking on the index in the left column, or by clicking on "Display all Sections" in the "Content Manager".

To find other Davis's Drug Guide topics, please login or purchase a subscription.