Route/Dosage

Epilepsy

• PO (Adults and Children >12 yr): 300 mg 3 times daily initially. Titration may be continued until desired (range is 900–1800 mg/day in 3 divided doses; doses should not be more than 12 hr apart). Doses up to 2400–3600 mg/day have been well tolerated.

• PO (Children >=5–12 yr): 10–15 mg/kg/day in 3 divided doses initially titrated upward over 3 days to 25–35 mg/kg/day in 3 divided doses; dosage interval should not exceed 12 hr (doses up to 50 mg/kg/day have been used).

• PO (Children 3–4 yrs): 10–15 mg/kg/day in 3 divided doses initially titrated upward over 3 days to 40 mg/kg/day in 3 divided doses; dosage interval should not exceed 12 hr (doses up to 50 mg/kg/day have been used).

• PO (Adults and Children >12 yr):
CCr 30–60 ml/min—300 mg twice daily;
CCr 15–30 ml/min—300 mg once daily;
CCr < 15 ml/min—300 mg once every other day; further adjustments are based on clinical response.

• PO (Adults): 300 mg once daily on first day, 300 mg twice daily on second day, then 300 mg three times/day on day 3, may then be titrated upward as needed up to 600 mg three times/day.

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