Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Severe hepatic or renal impairment

• Children or lactation

• Patients with supraventricular cardiac conduction defects or concurrent use of drugs that may slow heart rate (increased risk of bradycardia)

• History of ulcer disease/GI bleeding/concurrent NSAID use

• Severe asthma or obstructive pulmonary disease

• Mild to moderate renal impairment (avoid use if CCr <9 ml/min)

• Mild to moderate hepatic impairment (cautious dose titration recommended)

• May increase risk of cardiovascular mortality

• OB: Use only if potential benefit outweighs potential risk to fetus

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