Route/Dosage
• PO (Adults):
Immediate-release tablets4 mg twice daily initially, dose increments of 4 mg should be made at 4 wk intervals, up to 12 mg twice daily. Doses up to 16 mg twice daily have been used (range 16–32 mg/day;
Extended-release capsules— 8mg/day as a single dose in the morning, may be increased to 16 mg/day after 4 wk, then up to 24 mg/day after 4 wk, increments based on benefit/tolerability.
Renal Impairment• PO (Adults):
Moderate renal impairment—Daily dose should not exceed 16 mg.
Hepatic Impairment• PO (Adults):
Moderate hepatic impairment—Daily dose should not exceed 16 mg.
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