Patient/Family Teaching

Instruct patient to take medication as directed, at the same time each day,even if feeling better. Take missed doses as soon as remembered; if almost time for next dose, space missed dose and next dose 10–12 hr apart

» May cause dizziness or drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to medication is known.

» Advise patient to avoid taking OTC antacids within 2 hr of ketoconazole.

» Caution patient to wear sunglasses and to avoid prolonged exposure to bright light to prevent photophobic reactions

» Advise patient to use a nonhormonal form of contraception during ketoconazole therapy

» Advise patient to avoid concurrent use of alcohol while taking ketoconazole; may cause a disulfiram-like reaction (flushing, rash, peripheral edema, nausea, headache) and increase the risk of hepatotoxicity

» Instruct patient to notify health care professional if abdominal pain, fever, or diarrhea becomes pronounced or if signs and symptoms of liver dysfunction (unusual fatigue, anorexia, nausea, vomiting, jaundice, dark urine, or pale stools) occur

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