Pharmacokinetics

Absorption: Absorption from the GI tract is pH dependent; increasing pH decreases absorption

Distribution: Widely distributed. CNS penetration is unpredictable and minimal. Crosses the placenta; enters breast milk

Protein Binding: 99%

Metabolism and Excretion: Partially metabolized by the liver. Excreted in feces via biliary excretion

Half-life: 8 hr

TIME/ACTION PROFILE (blood levels)

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