Assessment

• Assess patient for symptoms of infection prior to and periodically during therapy

• Specimens for culture should be taken prior to instituting therapy. Therapy may be started before results are obtained

• Monitor hepatic function tests prior to and monthly for 3–4 mo and then periodically during therapy. May cause AST, ALT, serum alkaline phosphatase, and bilirubin concentrations. Ketoconazole should be discontinued if even minor abnormalities occur

» May cause serum testosterone concentrations

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