Implementation

• Do not confuse Oruvail (ketoprofen) with Elavil (amitriptyline)

» Administration in higher-than-recommended doses does not provide increased effectiveness but may cause increased side effects. Use lowest effective dose for shortest period of time

» Coadministration with opioid analgesics may have additive analgesic effects and may permit lower opioid doses

» Analgesic is more effective if given before pain becomes severe

• PO: For rapid initial effect, administer 30 min before or 2 hr after meals. Capsules may be administered with food, milk, or antacids containing aluminum hydroxide and magnesium hydroxide to decrease GI irritation

» Extended-release capsules should be swallowed whole; do not open or chew

• Dysmenorrhea: Administer as soon as possible after the onset of menses. Prophylactic treatment has not been proved effective

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