Interactions

Drug-Drug

• Concurrent use with carbamazepine may result in ↓ levels of lamotrigine and ↑ levels of an active metabolite of carbamazepine

• Lamotrigine levels are ↓ by concurrent use of phenobarbital , phenytoin , or primidone

• Concurrent use with valproic acid results in a twofold ↑ in lamotrigine levels, ↑ incidence of rash, and a ↓ in valproic acid level (lamotrigine dose should be ↓ by at least 50%)

• Oral contraceptives may ↓ serum levels of lamotrigine (dose adjustments may be necessary when starting and stopping oral contraceptives)

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