Interactions

Drug-Drug

• Concurrent use with carbamazepine may result in levels of lamotrigine and levels of an active metabolite of carbamazepine

• Lamotrigine levels are by concurrent use of phenobarbital, phenytoin, or primidone

• Concurrent use with valproic acid results in a twofold in lamotrigine levels, incidence of rash, and a in valproic acid level (lamotrigine dose should be by at least 50%)

• Oral contraceptives may serum levels of lamotrigine (dose adjustments may be necessary when starting and stopping oral contraceptives)

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