Davis's Drug Guide

levetiracetam

Implementation

Do not confuse Keppra with Kaletra (lopinavir/ritonavir)

» Iv doses should be used temporarily when oral route is not feasible. To convert IV to PO, equivalent dose and frequency may be used

PO: May be administered without regard to meals

• Administer tablets whole; do not administer partial tablets

Pedi: Patients <20 kg should receive oral solution. Administer with calibrated measuring device for accurate dose

• Discontinue gradually to minimize the risk of increase in seizure frequency



IV Adminstration:

Intermittent Infusion:
Diluent: Dilute dose in 100 mL of 0.9% NaCl, D5W, or LR. Do not administer solutions that are cloudy or contain particulate matter

Rate:
Infuse over 15 min

Y-Site Compatibility:

» diazepam

» lorazepam

» valproate



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