Route/Dosage
PO, IV (Adults): 500 mg twice daily initially; may be increased by 1000 mg/day at 2 wk intervals up to 3000 mg/day.
PO (Children 616 yrs): 10 mg/kg twice daily; may be increased at 2 wk intervals by 20 mg/kg increments up to 60 mg/kg/day.
Renal Impairment PO (Adults):
CCr 5080 ml/min5001000 mg q 12 hr initially;
CCr 3050 ml/min250750 mg q 12 hr initially;
CCr <30 ml/min250500 mg q 12 hr initially.
PO (Children and adolescents 415 yr): 20 mg/kg/day in 2 divided doses initially, may be increaed by 20 mg/kg/day every 2 wk up to 60 mg/kg/day in 2 divided doses as tolerated.
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