Davis's Drug Guide

LIDOCAINE

Action

IV, IM: Suppresses automaticity and spontaneous depolarization of the ventricles during diastole by altering the flux of sodium ions across cell membranes with little or no effect on heart rate

Local: Produces local anesthesia by inhibiting transport of ions across neuronal membranes, thereby preventing initiation and conduction of normal nerve impulses



Therapeutic Effect(s):

• Control of ventricular arrhythmias

• Local anesthesia



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