Contraindication/Precautions

Applies mainly to systemic use

Contraindicated in:

• Hypersensitivity; cross-sensitivity may occur

• Third-degree heart block

• Liver disease, CHF, patients weighing <50 kg, and geriatric patients (reduce bolus and/or maintenance dose)

• Respiratory depression

• Shock

• Heart block

• Pregnancy or lactation (safety not established)

• Children (safety not established for transdermal patch)

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