Interactions

Applies mainly to systemic use

Drug-Drug

• ↑ cardiac depression and toxicity with phenytoin , amiodarone , quinidine , procainamide , or propranolol

• Cimetidine , azole antifungals , clarithromycin , erythromycin , fluoxetine , nefazodone , paroxetine , protease inhibitors , ritonavir , verapamil , and beta blockers may ↓ metabolism and ↑ risk of toxicity

• Lidocaine may ↑ levels of calcium channel blockers , certain benzodiazepines , cyclosporine , fluoxetine , lovastatin , simvastatin , mirtazapine , paroxetine , ritonavir , tacrolimus , theophylline , tricyclic antidepressnts , and venlafaxine

• Effects of lidocaine may be ↓ by carbamazepine , phenobarbital , phenytoin , and rifampin

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