Interactions

Applies mainly to systemic use

Drug-Drug

• cardiac depression and toxicity with phenytoin, amiodarone, quinidine, procainamide, or propranolol

• Cimetidine, azole antifungals, clarithromycin, erythromycin, fluoxetine, nefazodone, paroxetine, protease inhibitors, ritonavir, verapamil, and beta blockers may metabolism and risk of toxicity

• Lidocaine may levels of calcium channel blockers, certain benzodiazepines, cyclosporine, fluoxetine, lovastatin, simvastatin, mirtazapine, paroxetine, ritonavir, tacrolimus, theophylline, tricyclic antidepressnts, and venlafaxine

• Effects of lidocaine may be by carbamazepine, phenobarbital, phenytoin, and rifampin

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