Absorption: Small amounts are systemically absorbed.
Distribution: Small amounts absorbed are widely distributed and cross the placenta and blood-brain barrier.
Metabolism and Excretion: Lidocainemostly metabolized by the liver. Prilocainemetabolized by the liver and kidneys.
Half-life: Lidocaine90120 min (EMLA); 26 hr (Oraqix): Prilocaine1050 min (EMLA); 26 hr (Oraqix).
TIME/ACTION PROFILE (local anesthesia)
|Top||1 hr(EMLA); 30 sec (Oraqix)||3 hr (EMLA)||12 hr (EMLA); 20 min (Oraqix)|
Following removal of occlusive dressing
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