Davis's Drug Guide
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lidocaine/prilocaine

Pharmacokinetics

Absorption: Small amounts are systemically absorbed.

Distribution: Small amounts absorbed are widely distributed and cross the placenta and blood-brain barrier.

Metabolism and Excretion: Lidocaine—mostly metabolized by the liver. Prilocaine—metabolized by the liver and kidneys.

Half-life: Lidocaine—90–120 min (EMLA); 2–6 hr (Oraqix): Prilocaine—10–50 min (EMLA); 2–6 hr (Oraqix).

TIME/ACTION PROFILE (local anesthesia)

ROUTEONSETPEAKDURATION
Top1 hr(EMLA); 30 sec (Oraqix)3 hr (EMLA)1–2 hr (EMLA)†; 20 min (Oraqix)

†Following removal of occlusive dressing

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