Pharmacokinetics

Absorption: Small amounts are systemically absorbed during 4-hr placement of EMLA system

Distribution: Small amounts absorbed are widely distributed and cross the placenta and blood-brain barrier

Metabolism and Excretion: Lidocaine—mostly metabolized by the liver. Prilocaine—metabolized by the liver and kidneys

Half-life: Lidocaine—7–30 min first phase, 90–120 min terminal phase: Prilocaine—10–50 min

TIME/ACTION PROFILE (local anesthesia)

ROUTE	ONSET	PEAK	DURATION†
Top	15 min	3 hr	1–2 hr

†Following removal of occlusive dressing

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