Concurrent use with class I antiarrhythmics including mexiletine may result in adverse cardiovascular effects.
Concurrent use with other local anesthetics may result in ↑ toxicity.
Concurrent use with sulfonamides , acetaminophen , chloroquine , nitroglycerin , nitroprusside , phenobarbital , phenytoin , or quinine in children ↑ the risk of methemoglobinemia (avoid concurrent use in children <12 mo).
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