Interactions

Drug-Drug

• ↑ risk of hypertensive response with MAO inhibitors , sympathomimetics (e.g., pseudoephedrine ), vasopressors (e.g., epinephrine , norepinephrine ), and dopaminergic agents (e.g., dopamine , dobutamine ); concurrent or recent use should be avoided

• ↑ risk of serotonin syndrome with SSRIs , TCAs , 5–HT1 agonists , meperidine , or buspirone ; concurrent use should be avoided

Drug-Food
Because of monoamine oxidase inhibitory properties, consumption of large amounts of foods or beverages containing tyramine should be avoided (↑ risk of pressor response. See Food Sources for Specific Nutrients)

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