Davis's Drug Guide

lithium

Pharmacokinetics

Absorption: Completely absorbed after oral administration

Distribution: Widely distributed into many tissues and fluids; CSF levels are 50% of plasma levels. Crosses the placenta; enters breast milk.

Metabolism and Excretion: Excreted almost entirely unchanged by the kidneys

Half-life: 20–27 hr

TIME/ACTION PROFILE (antimanic effects)

ROUTEONSETPEAKDURATION
PO, PO–ER 5–7 days10–21 days days



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