Interactions

Drug-Drug

• Do not use in patients receiving MAO inhibitors or procarbazine (may cause fatal reaction—contraindicated within 14–21 days of MAO inhibitor therapy)

• CNS depression with alcohol, antihistamines, and sedative/hypnotics

• Administration of agonist/antagonist opioid analgesics may precipitate opioid withdrawal in physically dependent patients

• Nalbuphine or pentazocine may analgesia

• Protease inhibitor antiretrovirals may effects and adverse reactions (concurrent use should be avoided)

• Phenytoin metabolism and may effects

• Chlorpromazine and thioridazine may the risk of adverse reactions (concurrent use should be avoided)

• May aggravate side effects of isoniazid

• Acyclovir may increase plasma concentrations of meperidine and normeperidine

• Concomitant use of kava, valerian or chamomile can CNS depression

• St. John's wort may increase serious side effects, concurrent use is not recommended

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