Implementation

• Provide safety measures as indicated. Supervise ambulation and transfer of patients

• PO: May be administered with food to minimize GI irritation. Tablets may be crushed and mixed with food or liquids to facilitate swallowing. For administration via NG tube, crush tablet and suspend in water or saline

• IM: Do not administer subcut. IM injections should contain no more than 5 ml (500 mg) at a time in the gluteal region

• Direct IV:
Diluent: Administer undiluted

• Concentration:
100 mg/ml.

• Rate:
Administer at a maximum rate of 180 mg/m2/min but not > 3 ml (300 mg)/min

• Intermittent Infusion:
Diluent: Dilute each dose in no more than 250 ml of 0.9% NaCl or D5W for injection.
Concentration: 4 mg/ml for slower infusions.Do not refrigerate after dilution
Have patient remain recumbent during and for at least 10–15 min after infusion to avoid orthostatic hypotension

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