Assessment

• Assess patient for pain, muscle stiffness, and range of motion before and periodically throughout therapy

• Monitor pulse and blood pressure every 15 min during parenteral administration

• Geri: Assess geriatric patients for anticholinergic effects (sedation and weakness)

• Assess patient for allergic reactions (skin rash, asthma, hives, wheezing, hypotension) after parenteral administration. Keep epinephrine and oxygen on hand in the event of a reaction

• Monitor IV site. Injection is hypertonic and may cause thrombophlebitis. Avoid extravasation

• Monitor renal function periodically during prolonged parenteral therapy (>3 days), because polyethylene glycol 300 vehicle is nephrotoxic

» May cause falsely increased urinary 5-hydroxyindoleacetic acid (5-HIAA) and vanillylmandelic acid (VMA) determinations

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