Implementation

• PO: Administer doses 30 min before meals and at bedtime

» Do not to remove orally disintegrating tablets from the bottle until just prior to dosing. Remove tablet from bottle with dry hands and immediately place on tongue to disintegrate and swallow with saliva. Tablet typically disintegrates in 1–1 ½ minutes. Administration with liquid is not necessary

• IM: For prevention of postoperative nausea and vomiting, inject IM near the end of surgery

• Direct IV:
Administer IV dose 30 min before administration of chemotherapeutic agent

• Rate:
Doses may be given slowly over 1–2 min. Rapid administration causes a transient but intense feeling of anxiety and restlessness followed by drowsiness

• Intermittent Infusion:

Diluent: May be diluted for IV infusion in 50 mL of D5W, 0.9% NaCl, D5/0.45% NaCl, Ringer's solution, or LR. Diluted solution is stable for 48 hr if protected from light or 24 hr under normal light

• Concentration:
May dilute to 0.2 mg/mL or give undiluted at 5 mg/mL.

• Rate:
Infuse slowly (maximum rate 5 mg/min) over at least 15–30 min

• Y-Site Compatibility:

» acyclovir

» aldesleukin

» alfentanil

» amifostine

» amikacin

» aminophylline

» ascorbic acid

» atracurium

» atropine

» azathioprine

» aztreonam

» bivalirudin

» bleomycin

» bumetanide

» buprenorphine

» butorphanol

» calcium chloride

» calcium gluconate

» carboplatin

» caspofungin

» cefazolin

» cefonicid

» cefoperazone

» cefotaxime

» cefotetan

» cefoxitin

» ceftazidime

» ceftizoxime

» ceftriaxone

» cefuroxime

» chloramphenicol

» chlorpromazine

» cimetidine

» ciprofloxacin

» cisatracurium

» cisplatin

» cladribine

» clindamycin

» cyanocobalamin

» cyclophosphamide

» cyclosporine

» cytarabine

» dactinomycin

» daptomycin

» dexamethasone

» dexmedetomidine

» digoxin

» diltiazem

» diphenhydramine

» dobutamine

» docetaxel

» dopamine

» doripenem

» doxapram

» doxorubicin hydrochloride

» doxycyline

» droperidol

» enalaprilat

» ephedrine

» epinephrine

» epirubicin

» epoetin alfa

» ertapenam

» erythromycin

» esmolol

» etoposide

» etoposide phosphate

» famotidine

» fenoldopam

» fentanyl

» filgrastim

» fluconazole

» fludarabine

» folic acid

» foscarnet

» gallium nitrate

» gemcitabine

» gentamicin

» glycopyrrolate

» granisetron

» heparin

» hetastarch

» hydrocortisone sodium succinate

» hydromorphone

» idarubicin

» ifosfamide

» imipenem/cilastatin

» indomethacin

» insulin

» isoproterenol

» ketorolac

» labetalol

» leucovorin

» levofloxacin

» lidocaine

» linezolid

» lorazepam

» magnesium sulfate

» mannitol

» mechlorethamine

» melphalan

» meperidine

» meropenem

» metaraminol

» methadone

» methotrexate

» methoxamine

» methyldopate

» methylprednisolone

» metoprolol

» metronidazole

» miconazole

» midazolam

» milrinone

» minocycline

» mitomycin

» morphine

» moxalactam

» multiple vitamins

» nafcillin

» nalbuphine

» naloxone

» nesiritide

» nitroglycerin

» nitroprusside

» norepinephrine

» octreotide

» ondansetron

» oxaliplatin

» oxytocin

» paclitaxel

» palonosetron

» pantoprazole

» papaverine

» pemetrexed

» penicillin G

» pentamidine

» pentazocine

» pentobarbital

» phenobarbital

» phentolamine

» phenylephrine

» phytonadione

» piperacillin/tazobactam

» potassium chloride

» procainamide

» prochlorperazine

» promethazine

» propranolol

» protamine

» pyridoxine

» quinupristin/dalfopristin

» ranitidine

» remifentanil

» rituximab

» rocuronium

» sargramostim

» sodium acetate

» sodium bicarbonate

» streptokinase

» succinylcholine

» sufentanil

» tacrolimus

» teniposide

» theophylline

» thiamine

» thiotepa

» ticarcillin/clavulanate

» tigecycline

» tirofiban

» tobramycin

» tolazoline

» topotecan

» trastuzumab

» trimethaphan

» urokinase

» vancomycin

» vasopressin

» vecuronium

» verapamil

» vinblastine

» vincristine

» vinorelbine

» voriconazole

» zidovudine

• Y-Site Incompatibility:

» amphotericin B cholesteryl

» amphotericin B colloidal

» amphotericin B liposome

» amsacrine

» cefepime

» dantrolene

» diazepam

» diazoxide

» doxorubicin liposome

» ganciclovir

» inamrinone

» phenytoin

» propofol

» trimethoprim/sulfamethoxazole

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