Davis's Drug Guide

metolazone

Pharmacokinetics

Absorption: Absorption is variable

Distribution: Unknown

Metabolism and Excretion: Excreted mainly unchanged by the kidneys

Half-life: 8 hr

TIME/ACTION PROFILE (diuretic effect†)

ROUTEONSETPEAKDURATION
PO 1 hr2 hr12–24 hr

†Full antihypertensive effect may take days–weeks



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