Implementation

• When changing from other antiarrhythmic therapy, give the 1st dose of mexiletine 6–12 hr after the last dose of quinidine, 3–6 hr after last dose of procainamide, or 8–12 hr after last dose of tocainide. When changing from parenteral lidocaine, decrease lidocaine dose or discontinue lidocaine 1–2 hr after administration of mexiletine or administer lower initial doses of mexiletine

» Transfer of patients with life-threatening arrhythmias from other antiarrhythmics to mexiletine should be managed in the hospital

• PO: Administer with food or antacids to minimize GI irritation

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