Davis's Drug Guide

norepinephrine

Pharmacokinetics

Absorption: IV administration results in complete bioavailability

Distribution: Concentrates in sympathetic nervous tissue. Does not cross the blood-brain barrier but readily crosses the placenta

Metabolism and Excretion: Taken up and metabolized rapidly by sympathetic nerve endings

Half-life: Unknown

TIME/ACTION PROFILE (effects on blood pressure)

ROUTEONSETPEAKDURATION
IVimmediaterapid1–2 min



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