Interactions

Drug-Drug

• Use with cyclopropane or halothane anesthesia , cardiac glycosides , doxapram , or local use of cocaine may result in ↑ myocardial irritability

• Use with MAO inhibitors , methyldopa , doxapram , or tricyclic antidepressants may result in severe hypertension

• Alpha-adrenergic blockers can prevent pressor response

• Beta blockers may exaggerate hypertension or block cardiac stimulation

• Concurrent use with ergot alkaloids ( ergotamine , ergonovine , methylergonovine , or oxytocin may result in enhanced vasoconstriction and hypertension

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