Interactions

Drug-Drug

• Omeprazole is metabolized by the CYP450 enzyme system and may compete with other agents metabolized by this system

• ↓ metabolism and may ↑ effects of antifungal agents , diazepam , digoxin , flurazepam , triazolam , cyclosporine ,, phenytoin , saquinavir , tacrolimus , and warfarin

• May ↓ absorption of drugs requiring acid pH, including ketoconazole , itraconazole , ampicillin , iron salts , and digoxin

• Has been used safely with antacids

• May significantly ↓ effects of atazanavir and nelfinavir (concurrent use not recommended)

• May ↑ risk of bleeding with warfarin (monitor INR/PT)

• May ↓ the antiplatelet effects of clopidogrel

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