Davis's Drug Guide

orphenadrine

Pharmacokinetics

Absorption: Readily absorbed after oral and IM administration; IV administration results in complete bioavailability

Distribution: Unknown

Metabolism and Excretion: Mostly metabolized by the liver

Half-life: 14 hr

TIME/ACTION PROFILE (skeletal muscle effects)

ROUTEONSETPEAKDURATION
PO-ERwithin 1 hr6–8 hr12 hr
IM5 min30 min12 hr
IVimmediateunknown12 hr



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