Interactions

Drug-Drug

• Induces liver enzymes and may hasten metabolism and ↓ effectiveness of other drugs metabolized by the liver, including hormonal contraceptives , chloramphenicol , acebutolol , propranolol , metoprolol , timolol , doxycycline , corticosteroids , tricyclic antidepressants , phenothiazines , and quinidine

• Additive CNS depression with other CNS depressants , including alcohol , antihistamines , opioid analgesics , and sedative/hypnotics

• Concurrent use with phenobarbital may lead to phenobarbital toxicity

Drug-Natural Products

• Concomitant use of kava , valerian , skullcap , chamomile , or hops can ↑ CNS depression

• See sedative interactions

• St. John's wort may affect primidone levels and effectiveness; avoid use

Drug-Food
↓ the absorption of folic acid

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