Davis's Drug Guide

procarbazine

Pharmacokinetics

Absorption: Well absorbed following oral administration

Distribution: Widely distributed; crosses the blood-brain barrier

Metabolism and Excretion: Metabolized by the liver; <5% excreted unchanged by the kidneys; some respiratory elimination as methane and carbon dioxide

Half-life: 1 hr

TIME/ACTION PROFILE (effects on blood counts)

ROUTEONSETPEAKDURATION
PO14 days2–8 wk28 days or more (up to 6 wk)



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