Interactions

Drug-Drug

• Concurrent use with sympathomimetics including methylphenidate may produce life-threatening hypertension (avoid concurrent use during and for 14 days following procarbazine)

• Deep coma and death may result from concurrent use of opioid analgesics; avoid meperidine. Use small incremental doses of other agents and titrate to effect

• bone marrow depression may occur with other antineoplastics or radiation therapy

• Seizures and hyperpyrexia may occur with concurrent use of MAO inhibitors, tricyclic antidepressants, SSRI antidepressants (should not be used within 5 wk of fluoxetine), or carbamazepine

• May serum digoxin levels

• Concurrent use with levodopa may result in flushing and hypertension

• CNS depression with other CNS depressants, including alcohol, antidepressants, antihistamines, opioid analgesics, phenothiazines, and sedative/hypnotics

• Disulfiram-like reaction may occur with alcohol

• Cigarette smoking may the risk of secondary lung cancer

• Ingestion of foods high in tyramine content (see Food Sources for Specific Nutrients) may result in hypertension

• Ingestion of foods high in caffeine content may result in arrhythmias

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