Implementation

• Do not confuse prochlorperazine with chlorpromazine

» To prevent contact dermatitis, avoid getting solution on hands

» Phenothiazines should be discontinued 48 hr before and not resumed for 24 hr after myelography; they lower seizure threshold

• PO: Do not crush or chew extended-release capsules Administer with food, milk, or a full glass of water to minimize gastric irritation

» Dilute syrup in citrus or chocolate-flavored drinks

» Do not open, crush, or chew extended-release capsules

• IM: Do not inject subcut. Inject slowly, deep into well-developed muscle. Keep patient recumbent for at least 30 min after injection to minimize hypotensive effects. Slight yellow color will not alter potency. Do not administer solution that is markedly discolored or that contains a precipitate

• Direct IV:

Concentration: Dilute to a concentration of 1 mg/ml

• Rate:
Administer at a rate of 1 mg/min; not to exceed 5 mg/min

• Intermittent Infusion:

Diluent: Dilute 20 mg in up to 1 L dextrose, saline, Ringer's or LR, dextrose/saline, dextrose/Ringer's, or lactated Ringer's combinations

• Continuous Infusion:
Has been used as infusion with 20mg/L of compatible solution

• Syringe Incompatibility:
Manufacturer does not recommend mixing prochlorperazine with other medications in syringe

• Y-Site Compatibility:

» amsarcine

» calcium gluconate

» cisatracurium

» cisplatin

» cladribine

» cyclophosphamide

» cytarabine

» dexmedetomidine

» doxorubicin

» doxorubicin liposome

» fluconazole

» granisetron

» heparin

» hydrocortisone sodium succinate

» linezolid

» melphalan

» methotrexate

» ondansetron

» oxaliplatin

» paclitaxel

» potassium chloride

» propofol

» remifentanil

» sargramostim

» sufentanil

» teniposide

» thiotepa

» topotecan

» vinorelbine

» vitamin B complex with C

• Y-Site Incompatibility:

» aldesleukin

» allopurinol

» amifostine

» amphotericin B cholesteryl

» amifostine

» aztreonam

» bivalirudin

» cefepime

» etoposide phosphate

» fenoldopam

» filgrastim

» fludarabine

» foscarnet

» gemcitabine

» pemetrexed

» piperacillin/tazobactam

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