Interactions
Drug-Drug
Any inhibitors of the CYP1A2, CYP2D6 or CYP3A4 enzyme systems may
levels, including desipramine, paroxetine, ritonavir, sertraline, ketoconazole, saquinavir, erythromycin (blood level monitoring recommended)
Quinidine is a strong inhibitor of CYP2D6 and significantly
levels of propafenone; concurrent use is not recommended
Propafenone is also an inhibitor of CYP2D6 and may
levels of desipramine, imipramine, haloperidol, and venlafaxine
Significantly
serum digoxin levels(blood level monitoring recommended,
dose may be required)
blood levels of metoprolol and propranolol (
dose may be required)
Concurrent use of local anesthetics may
risk of CNS adverse reactions
effects of warfarin (
warfarin dose if necessary, monitor prothrombin time)
Concurrent with amiodarone can adversely effect conduction/repolarization and should be avoided
May
risk of CNS adverse reactions with lidocaine
May
cyclosporine through blood levels and risk of nephrotoxicity
Rifampin may
serum levels and effectiveness of propafenone
Cimetidine may
serum levels
Drug-FoodGrapefruit juice may

levels
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