Interactions

Drug-Drug

• Any inhibitors of the CYP1A2, CYP2D6 or CYP3A4 enzyme systems may levels, including desipramine, paroxetine, ritonavir, sertraline, ketoconazole, saquinavir, erythromycin (blood level monitoring recommended)

• Quinidine is a strong inhibitor of CYP2D6 and significantly levels of propafenone; concurrent use is not recommended

• Propafenone is also an inhibitor of CYP2D6 and may levels of desipramine, imipramine, haloperidol, and venlafaxine

• Significantly serum digoxin levels(blood level monitoring recommended, dose may be required)

• blood levels of metoprolol and propranolol ( dose may be required)

• Concurrent use of local anesthetics may risk of CNS adverse reactions

• effects of warfarin ( warfarin dose if necessary, monitor prothrombin time)

• Concurrent with amiodarone can adversely effect conduction/repolarization and should be avoided

• May risk of CNS adverse reactions with lidocaine

• May cyclosporine through blood levels and risk of nephrotoxicity

• Rifampin may serum levels and effectiveness of propafenone

• Cimetidine may serum levels

Drug-Food
Grapefruit juice may levels

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