Route/Dosage

• IV (Adults and Children):
Heparin overdose—1 mg/100 units of heparin. If given >30 min after heparin, give 0.5 mg/100 units of heparin (not to exceed 100 mg/2 hr). Further doses should be determined by coagulation tests. If heparin was administered subcutaneously, use 1–1.5 mg protamine per 100 units of heparin, give 25–50 mg of the protamine dose slowly followed by a continuous infusion over 8–16 hours
Enoxaparin overdose—1 mg/each mg of enoxaparin to be neutralized (unlabeled).
Dalteparin overdose—1 mg/100 anti-Xa IU of dalteparin. If required, a second dose of 0.5 mg/100 anti-Xa IU of dalteparin may be given 2–4 hr later if laboratory assessment indicates need (unlabeled).

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