Assessment

Malaria

• Assess patient for improvement in signs and symptoms of condition daily during therapy

• May cause ↑ urinary 17-ketogenic steroids when metyrapone or Zimmerman method is used

• Plasma quinine levels of >10 mcg/mL may cause tinnitus and impaired hearing

» Signs of toxicity or cinchonism include tinnitus, headache, nausea, and slightly disturbed vision; usually disappear rapidly upon discontinuing quinine

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