Interactions

Drug-Drug

• Inhibits the cytochrome P450 3A4 drug metabolizing enzyme system; inhibits metabolism of cyclosporine, midazolam, and nifedipine and risk of toxicity (careful monitoring required)

• Similar effects may be expected with concurrent use of delavirdine, nevirapine, indinavir, ritonavir, vinca alkaloids, docetaxel, paclitaxel, diazepam, verapamil, diltiazem, HMG CoA reductase inhibitors, tacrolimus, methylprednisolone, carbamazepine, quinidine, lidocaine, and disopyramide

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