Interactions

Drug-Drug

• Blood levels and effects may be ↓ by phenytoin , carbamazepine , or valproic acid

• May ↑ blood levels and effects of phenytoin or amitriptyline

• May ↓ blood levels and effects of hormonal contraceptives , risperidone , lithium or valproic acid

• ↑ risk of CNS depression with alcohol or other CNS depressants

• Carbonic anhydrase inhibitors ( acetazolamide ) may ↑ risk of kidney stones

• Concurrent use with valproic acid may ↑ risk of hyperammonemia/encephalopathy

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