Route/Dosage

• SC (Adults): 1.25 ng/kg/min, may be reduced to 0.625 ng/kg/min if intolerance occurs. Increments of no more than 1.25 ng/kg/min may be made weekly for the first 4 wk and then no more than 2.5 ng/kg/min weekly for the remainder of therapy up to 40 ng/kg/min. Avoid abrupt discontinuation or rapid decrease in dosing. Infusion rate may be calculated with the following formula: Infusion rate (ml/hr) = Dose (ng/kg/min) × weight (kg) × [0.00006/treprostinil dose strength concentration (mg/ml) ].

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