Interactions

Drug-Drug

• Additive hypotension with antihypertensives , acute ingestion of alcohol , or nitrates

• Additive CNS depression with other CNS depressants , including alcohol , antihistamines , opioids , sedative/hypnotics , and general anesthetics

• Additive anticholinergic effects with other drugs having anticholinergic properties , including antihistamines , antidepressants , other phenothiazines , quinidine , and disopyramide

• Acute encephalopathy may occur with lithium

• May ↓ the effectiveness of levodopa

• ↑ risk of agranulocytosis with antithyroid drugs

• Lithium ↓ absorption and may ↑ risk of extrapyramidal reactions

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