Pharmacokinetics
Absorption: Well absorbed from the GI tract
Distribution: Widely distributed. Crosses the blood-brain barrier and placenta and enters breast milk
Metabolism and Excretion: Some metabolism by the liver (20%); remainder excreted unchanged by the kidneys
Half-life: Trimethoprim—6–11 hr; sulfamethoxazole—9–12 hr, both prolonged in renal failure
TIME/ACTION PROFILE (blood levels)
| ROUTE | ONSET | PEAK | DURATION |
| PO | rapid | 2–4 hr | 6–12 hr |
| IV | rapid | end of infusion | 6–12 hr |
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